Kidney cancer model zebrafish
Web15 jan. 2024 · Zebrafish is a promising model organism for human disease including hepatocellular cancer (HCC). Recently, zebrafish has emerged also as a host for xenograft studies of liver cancer cell lines and patient derived tumors of HCC. Web1 sep. 2010 · The zebrafish offers a number of features, such as its rapid development, tractable genetics, suitability for in vivo imaging and chemical screening, that make it an attractive model to cancer researchers. This Primer will provide a synopsis of the different cancer models generated by the zebrafish community to date.
Kidney cancer model zebrafish
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Web31 mrt. 2024 · The zebrafish model has already proved its merit for the study of cardiovascular physiology, disease and regeneration. It has helped us to better understand the development of the cardiovascular system as well as regenerative mechanisms and the roles of essential signaling pathways. In recent years, the rise of CRISPR/Cas9 and … Web1 jan. 2005 · Polycystic kidney disease. ... It is possible to model cancer in the zebrafish using various transgenic fish. So far, there are excellent models of leukaemia and melanoma in the zebrafish 20,34,35.
Web14 apr. 2024 · Mutation of the ataxia-telangiectasia mutated (atm) gene in humans and mice renders them susceptible to tumors due to both its role as a DNA damage sensor acting in pre-malignant cells to activate Tp53 and to its role in sensing and reducing oxidative stress.The oncogene UHRF1 is overexpressed in many cancers and we previously … WebZebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular …
Web9 aug. 2016 · In addition to utilizing zebrafish disease models to characterize human diseases, researchers can also identify and test new drugs to treat the diseases being … WebThe kidneys are a pair of kidney bean-shaped organs, located above the waist on either side of the spine, that filter and clean blood and produce urine. The most common adult …
WebThe zebrafish kidney represents a useful model of kidney development and disease (Drummond & Davidson 2010). The van Eeden lab generated two zebrafish lines with …
Web3 mrt. 2024 · Zebrafish (Danio rerio) has been proven to be a flexible and authentic animal model to study diverse diseases because of its fully sequenced genome, high fecundity, and easy manipulation for ... hardstyle osu mapsWebKidney cancer has three main types. Renal cell cancer, or renal cell adenocarcinoma, forms in the tubules of the kidney. Transitional cell carcinoma forms in the renal pelvis … hardstyle osuWeb11 apr. 2015 · Using the anatomically simple zebrafish kidney, researchers hope to provide insights into kidney regeneration mechanisms with the promise of developing future … hardtop xp jotun msdsWebKey facts. The use of zebrafish (Danio rerio) as a model organism began in the 1960s.The zebrafish is a tropical fish native to southeast Asia. The zebrafish is about 2.5 cm to 4 cm long. In its larval stages it is transparent and as it matures to an adult it develops stripes that run along the length of the body and look blue in colour. hardin tessa movieWebOverview. Kidney cancer can develop in adults and children. The main types of kidney cancer are renal cell cancer, transitional cell cancer, and Wilms tumor. Certain … hardtop xp jotun datasheetWeb23 aug. 2013 · The zebrafish is a recent addition to animal models of human cancer, and studies using this model are rapidly contributing major insights. Zebrafish develop … hardtail e mountain bikesWeb10 jun. 2024 · With the aim of challenging zebrafish xenografts as an in vivo screening platform for bevacizumab responses, we used several representative tumor cell models of triple negative breast cancer (TNBC ... hardvision la rioja