WebThe globin genesare organized into two clusters (Figure 116-6). The α-like genes are located along a 20-kb distal segment of the short arm of chromosome 16. The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members include myoglobin and hemoglobin. Both of these proteins reversibly bind oxygen … See more Globin superfamily members share a common three-dimensional fold. This 'globin fold' typically consists of eight alpha helices, although some proteins have additional helix extensions at their termini. Since the globin … See more Globins evolved from a common ancestor and can be divided into three lineages: • Family M (for myoglobin-like) or F (for FHb-like), which has a typical 3/3 fold. • Family S (for … See more Human genes encoding globin proteins include: • CYGB • HBA1, HBA2, HBB, HBD, HBE1, HBG1, HBG2, HBM, HBQ1, HBZ, MB The globins include: • See more • Leghaemoglobin InterPro: IPR001032 • Myoglobin InterPro: IPR002335 • Erythrocruorin InterPro: IPR002336 • Hemoglobin, beta InterPro: IPR002337 See more The globin fold (cd01067) also includes some non-haem proteins. Some of them are the phycobiliproteins, the N-terminal domain of See more • Biology portal • C-rich stability element • Globular protein • Hemoglobin See more
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WebAug 15, 2005 · Those genes subsequently evolved and were modified by a variety of genetic processes, including duplication events. 1 In humans, the α-globin gene family resides on chromosome 16p13.3 and is composed of a cluster of 3 genes (ζ2-α2-α1) with protein products that bind heme and assemble into hemoglobin. WebMar 8, 2024 · Globin-like protein superfamily. This globin-like domain superfamily contains a wide variety of all-helical proteins that bind porphyrins, phycobilins, and other non … adi mantova
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WebNov 22, 2013 · It describes the basic globin structure and its variations; the taxonomic distribution of different types of globins; and the variety of known functions, focusing on … WebJan 19, 2015 · As multigene families go, the globin family is relatively simple and easy to understand. There are only about a dozen loci involved, one isolated locus (myoglobin) and two clusters of loci ($\alpha- and β\beta-globins). You’ll find a diagram of the β\beta-globin cluster in Figure 2. As you can see the β\beta-globins are not only ... WebNeuroglobin and cytoglobin are two recently discovered members of the vertebrate globin family. Both are intracellular proteins endowed with hexacoordinated heme-Fe atoms, in their ferrous and ferric forms, and display O2 affinities comparable with that of myoglobin. adi marvell