Ctcf myc
WebYY1 has a similar role to CTCF, plays a role in looping and 3D chromatin organization. Oct4 is a Yamanaka factor. It is used to create induced pluripotent stem cells (with other proteins (myc...)) SUMOylation; Phoshorylation by protein kinase CK; CTCF can bind to enhancer, promoter, intergenic regions to mediate loop formation (TAD, sub-TAD ... WebOct 12, 2024 · DLGAP1-AS2 directly binds to CTCF and activates Myc transcription. Given that CTCF is a key regulator of Myc, we then tested whether CTCF is involved in DLGAP1-AS2-mediated Myc regulation. As shown in Fig. 5A, silencing of …
Ctcf myc
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WebSep 29, 2014 · CTCF, which is known for its role as chromatin organiser, is thought to be involved in the activation of C-MYC expression. The affinity of CTCF to its binding site on the DNA is negatively... WebJun 26, 2009 · CTCF was first isolated and cloned by Lobanenkov and colleagues on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter-proximal regulatory region of the chicken c-myc gene (Klenova et al., 1993, Lobanenkov et al., 1990) and immediately downstream of two conserved alternative TSSs in the …
WebApr 13, 2024 · MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. However, the functional link between the two master regulators has not been reported. In this study, we find that MYC rewires prostate ... WebJan 10, 2003 · The understanding of MYC regulation by CTCF noted above suggested that CTCF induction, repressing MYC transcription, might be pivotal to growth arrest and apoptosis in immature B cells. Here, we …
WebMay 25, 2024 · INTRODUCTION. CCCTC-binding factor (CTCF) is a transcription factor with 11 zinc finger domains ubiquitously expressed in cells of eukaryotes. Initially identified as … WebJun 23, 2024 · In addition to well-known universal functions of chromosomal CTCF (and to a lesser known centrosomal CTCF functions) expressed …
WebTranscriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the …
WebThe effects of CTCF on the transcription of MYC, ARF and p53 are certainly nucleoplasmic and the ARF-BP1-CTCF interactions are equally certain to be nuclear and directly … full mouse pad gamingWebMar 30, 2024 · MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. … full mounted white tigerWebSep 29, 2014 · Here, the copy number of C-MYC of five different prostate cancer cell lines has been determined by FISH, and the state of methylation of the binding site of CTCF … full mourners outfitWebJul 26, 2024 · Whole transcriptome analysis showed hundreds of genes differentially expressed in CTCF-depleted cells, among which MYC and a number of MYC target … full mousepadsWebJun 28, 2024 · CCCTC-binding factor (CTCF) was first identified as a nuclear DNA-binding protein, which negatively regulates chicken c-myc expression by interacting with three regularly spaced repeats of the CCCTC DNA motif . Since then, considerable attention has been focused on CTCF leading to pivotal discoveries related to its structure, binding … full mouse pad gaming deskWeb代謝產物活化蛋白(CAP,Catabolite activator protein),也稱為cAMP受體蛋白(CRP,cAMP Receptor Protein),為一種轉錄促進劑,以同型二聚體的方式存在。 其在結合上DNA時會同時彎曲DNA結構,促進RNA聚合酶的結合,加快轉錄速度。. 其結合在 乳糖操作子 ( 英语 : lac operon ) 的啟動子上後,會促進該操作子的轉錄。 full mouse empty mouseWebPositive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. ... (CTCF), have emerged. We analyzed zebrafish embryos null for cohesin subunit rad21 using microarrays to determine global effects of cohesin on gene expression during embryogenesis. This identified Rad21-associated gene networks that included myca … gingin road lancelin